Yes it can be done and it's relatively easy to do. You need to create 3 files - a udev rule, and two scripts.

UDEV Rule

A UDEV rule would detect a mouse plug event and trigger a script whenever the event happens. Create a file under /etc/udev/rules.d:

sudo gedit /etc/udev/rules.d/42-kill-mouse-accel.rules

Paste the following line in it:

ACTION=="add", ATTRS{bInterfaceClass}=="03", ENV{DISPLAY}=":0.0", ENV{XAUTHORITY}="/home/[YOUR_USER_NAME]/.Xauthority", ENV{ID_CLASS}="mouse", RUN+="/usr/local/bin/kill-mouse-accel.sh"

Note the part that says [YOUR_USER_NAME], you have to replace it with your user name.

Save and exit Gedit.

Acceleration Script

The acceleration script would be the code triggered by the UDEV rule, which in turn would fork a worker script in the background. The background script would do the actual work. We do that since we want to wait a bit before changing acceleration but we don't want to block UDEV. Create a file under /usr/local/bin:

sudo gedit /usr/local/bin/kill-mouse-accel.sh 

Paste the following code in it:

#!/bin/bash 



export DISPLAY=${DISPLAY} 

/usr/local/bin/kill-mouse-accel-worker.sh &

Save and exit Gedit.

Background Acceleration Script

This script is where the command disabling mouse acceleration is called. Create a file under /usr/local/bin:

sudo gedit /usr/local/bin/kill-mouse-accel-worker.sh

Paste the following code in it:

#!/bin/bash 



sleep 2 



for i in $(xinput list | grep [Mm]ouse | sed -e 's/^.*id=([0-9]*.).*$/1/') 

do 

    echo "Found device: $i" 



    # The command disabling mouse acceleration

    xinput set-ptr-feedback $i 10 1 1 

done

Save and exit Gedit.

Finalization and Testing

Make both scripts executable:

sudo chmod +x /usr/local/bin/kill-mouse-accel.sh /usr/local/bin/kill-mouse-accel-worker.sh

Restart UDEV:

sudo service udev restart

Finally, re-plug your USB mouse and wait for a few seconds. Mouse acceleration should be disabled.

Credits

Credit goes to the author of the following blog post: http://granjow.net/udev-rules.html