This is how I see it. When I used to run "No Script" it wasn't so much because I was worried about viruses or malware, but because I didn't want advertising companies tracking what I was doing. So while No Script on a Windows system is good for virus prevention, and a few other things. Running No Script on and Unix based system will still protect you - for the most part - from wandering eyes tracking your online activities.

So in short if you were wanting to run No Script to protect you from viruses, then no its not really necessary. But if you wanting to run it for pretty much any of its other uses, then yah you can go ahead and run it. Hope I was of some help.