Yes, this is very much possible.

You simply need to turn on mouse support in your ~/.byobu/.tmux.conf configuration.

Add the following:

set -g mouse-select-pane on

set -g mouse-select-window on

set -g mouse-resize-pane on

set -g mouse-utf8 on

This will allow you to:

• select a split by clicking in it


• select a window by clicking on it in your status bar


• resize a split by grabbing the border and dragging

However, you may now find it difficult to use your mouse to click on some text, and highlight (select) it. To do this, you'll now need to use either Shift-LeftClick or Ctrl-LeftClick.

Full disclosure: I am the author and maintainer of Byobu.